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Single-strain improved oral cholera vaccine : scientific report- Jan Holmgren

Single-strain improved oral cholera vaccine : scientific report- Jan Holmgren

Detaljer

Single-strain improved oral cholera vaccine : scientific report- Jan Holmgren
Publikationsnummer
MSB920
ISBN-nummer
Utgivningsår
2015
Omfång (sidor)
14 s.
Pris
0 :-
There is an urgent need for effective and affordable cholera vaccines both for use in cholera outbreaks and in mass vaccination campaigns. The main goal of the project has been to develop a simplified killed oral cholera vaccine based on a single Vibrio cholerae O1 vaccine strain and a single inactivation method, which could replace three virulent O1 strains inactivated by two different methods used in current licensed vaccines thereby reducing production costs. The vaccine should ideally also contain recombinantly produced low-cost cholera toxin B subunit (rCTB) and be in a formulation that would avoid both the need for a cold chain and for co-administration of a bicarbonate buffer.

Senast granskad: 2 september 2019

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